Treatment must be started within 8h of ingestion to achieve maximum protection.Protects against paracetamol-induced hepatoxicity by restoring glutathione levels.Build-up of NAPQI causes toxicity in centrilobular hepatocytes.↓ glutathione storage with ↑ NAPQI during paracetamol overdose.The toxic metabolite, NAPQI is formed in paracetamol overdose.Paracetamol metabolism: 20% in the small intestines, 80% by the liver.Late (2-3 days): Evidence of hepatic failure i.e RUQ pain, jaundice, encephalopathy.
Early (First 24h): None/nausea/vomiting/vague abdominal pain.Weight >110kg – Toxic dose calculated with a max weight of 110kg.Pregnancy – Toxic dose calculated using the patient’s pre-pregnancy weight.Recommended paracetamol dose in adults = 4g or 75mg/kg in 24h.The app allows you to sign up with an NHS email. As it is quite common, the information below is to help give you an overview.įor management, use Toxbase, the login should be on your trust intranet or from A&E. As an FY1, you will encounter these either during clerking shifts or you may look after them on the ward.
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